Article
Regulation of human monocyte HLA-DR and CD4 antigen expression, and antigen presentation by 1,25-dihydroxyvitamin D3.
Blood - 1 Jul 1990
Rigby W F, Waugh M, Graziano R F
Abstract excerpt
1,25-Dihydroxyvitamin D3 (1,25(OH)2-D) has been shown to be a macrophage-derived cytokine, capable of regulating myeloid differentiation and T-cell activation in vitro. Therefore, we examined the effects of 1,25(OH)2-D on the monocyte phenotype and function of human peripheral blood monocytes as an index of its biologic role at an inflammatory site. 1,25(OH)2-D treatment consistently and specifically reduced...
Topics
- Antibody-Dependent Cell Cytotoxicity
- Antigen-Presenting Cells
- CD4 Antigens
- Calcitriol
- Gene Expression Regulation
- HLA-DR Antigens
- Humans
- Immunity, Cellular
- Lymphocyte Activation
- Macrophages
- Monocytes