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Article

Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D.

The Journal of clinical endocrinology and metabolism - 1 Jul 2010

Chun Rene F, Lauridsen Anna L, Suon Lizabeth, Zella Lee A, Pike J Wesley, Modlin Robert L, Martineau Adrian R, Wilkinson Robert J, Adams John, Hewison Martin

Abstract excerpt

BACKGROUND: Serum 25-hydroxyvitamin D (25OHD) is a key factor in determining monocyte induction of the antimicrobial protein cathelicidin, which requires intracrine conversion of 25OHD to 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. Both vitamin D metabolites circulate bound to vitamin D-binding protein (DBP), but the effect of this on induction of monocyte cathelicidin remains unclear. METHODS: Human monocytes were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20427486
DOI: 10.1210/jc.2010-0195
PMCID: PMC2928899

Genes

DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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