Article
1,25 dihydroxyvitamin D3 limits monocyte maturation in lupus sera.
Lupus - 1 Jun 2011
Lerman Ma, Burnham Jm, Behrens Em
Abstract excerpt
In this study we examined whether treatment with 1,25-dihydroxyvitaminD(3) (1,25(OH)(2)D(3)) affects human APC maturation in vitro under multiple cytokine milieus. Human monocytes were elutriated from whole blood, incubated with human sera in the presence or absence of 1,25(OH)(2)D(3), and stimulated with IFNα, GM-CSF/IL-4, or were cultured without stimulatory cytokines. Incubation of control monocytes with...
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