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Article

Evolving abundance and clonal pattern of human germinal center B cells during childhood.

Blood - 1 Jul 1990

Valles-Ayoub Y, Govan H L, Braun J

Abstract excerpt

Childhood is a critical period for the development of the memory B-lymphocyte repertoire necessary in protective humoral immunity. This study addressed the natural history of memory B cells based on the previous identification of germinal center and mantle zone cells as the probable precursor and mature memory cell populations, respectively. Using flow cytometric quantitation of these B-cell subpopulations in...

Topics

Adolescent
B-Lymphocytes
Cell Differentiation
Cell Separation
Child
Child, Preschool
Clone Cells
Flow Cytometry
Humans
Palatine Tonsil
Phenotype
Polymerase Chain Reaction

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PMID: 2364168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2364168-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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