Article
Intermolecular disulfide bonds between nucleoporins regulate karyopherin-dependent nuclear transport.
Journal of cell science - 15 Jul 2013
Yoshimura Shige H, Otsuka Shotaro, Kumeta Masahiro, Taga Mariko, Takeyasu Kunio
Abstract excerpt
Disulfide (S-S) bonds play important roles in the regulation of protein function and cellular stress responses. In this study, we demonstrate that distinct sets of nucleoporins (Nups), components of the nuclear pore complex (NPC), form S-S bonds and regulate nuclear transport through the NPC. Kin...
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