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Article

Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system.

Molecular biology of the cell - 1 Oct 2011

Gross Dominik P, Burgard Caroline A, Reddehase Silvia, Leitch Jeffry M, Culotta Valeria C, Hell Kai

Abstract excerpt

The copper chaperone for superoxide dismutase 1 (Ccs1) provides an important cellular function against oxidative stress. Ccs1 is present in the cytosol and in the intermembrane space (IMS) of mitochondria. Its import into the IMS depends on the Mia40/Erv1 disulfide relay system, although Ccs1 is, in contrast to typical substrates, a multidomain protein and lacks twin Cx(n)C motifs. We report on the molecular...

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PMID: 21865601
DOI: 10.1091/mbc.E11-04-0296
PMCID: PMC3192856

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