Article
Integrative structure-function mapping of the nucleoporin Nup133 suggests a conserved mechanism for membrane anchoring of the nuclear pore complex.
Molecular & cellular proteomics : MCP - 1 Nov 2014
Kim Seung Joong, Fernandez-Martinez Javier, Sampathkumar Parthasarathy, Martel Anne, Matsui Tsutomu, Tsuruta Hiro, Weiss Thomas M, Shi Yi, Markina-Inarrairaegui Ane, Bonanno Jeffery B, Sauder J Michael, Burley Stephen K, Chait Brian T, Almo Steven C, Rout Michael P, Sali Andrej
Abstract excerpt
The nuclear pore complex (NPC) is the sole passageway for the transport of macromolecules across the nuclear envelope. Nup133, a major component in the essential Y-shaped Nup84 complex, is a large scaffold protein of the NPC's outer ring structure. Here, we describe an integrative modeling approach that produces atomic models for multiple states of Saccharomyces cerevisiae (Sc) Nup133, based on the crystal...
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