Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice.

Oncogene - 30 Jan 2014

Watanabe K, Fallahi M, Dai X

Abstract excerpt

Little is known about chromatin mechanisms that regulate tumor-initiating cells that are proposed to be responsible for tumor recurrence and relapse. We have previously shown that Pygopus 2 (Pygo2), a chromatin effector and context-dependent Wnt signaling coactivator, regulates mammary gland development by expanding epithelial stem/progenitor cells. However, the role of Pygo2 in mammary tumorigenesis in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anthelmintics
Share to Chromatin
Share to Mammary Glands, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Animal

Share to Mammary Tumor Virus, Mouse

Share to Neoplastic Stem Cells

Share to Wnt Signaling Pathway

Share to Wnt1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 23334328
DOI: 10.1038/onc.2012.620
PMCID: PMC3913260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice.PMID 23334328Read ↗

Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation.Semantic proximity Read ↗

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate CancerSemantic proximity Read ↗

Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.Semantic proximity Read ↗

The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.Semantic proximity Read ↗

Developmental Stage and Cellular Context Determine Oncogenic and Molecular Outcomes of <i>Ezh2</i> <sup>Y641F</sup> Mutation in HematopoiesisSemantic proximity Read ↗

Transcriptomic dynamics of breast cancer progression in the MMTV-PyMT mouse modelSemantic proximity Read ↗

Runx1 is associated with breast cancer progression in MMTV‐PyMT transgenic mice and its depletion in vitro inhibits migration and invasionSemantic proximity Read ↗

E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer.Semantic proximity Read ↗

The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cellsSemantic proximity Read ↗

Runx2 contributes to the regenerative potential of the mammary epitheliumSemantic proximity Read ↗

Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast CancerSemantic proximity Read ↗

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.