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Article

Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2.

Genesis (New York, N.Y. : 2000) - 1 May 2007

Li Boan, Rhéaume Catherine, Teng Andy, Bilanchone Virginia, Munguia Jesus E, Hu Ming, Jessen Shannon, Piccolo Stefano, Waterman Marian L, Dai Xing

Abstract excerpt

Canonical Wnt signaling involves complex intracellular events culminating in the stabilization of beta-catenin, which enters the nucleus and binds to LEF/TCF transcription factors to stimulate gene expression. Pygopus was identified as a genetic modifier of Wg (Wnt homolog) signaling in Drosophila, and encodes a PHD domain protein that associates with the beta-catenin/LEF/TCF complex. Two murine pygopus paralogs,...

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PMID: 17458864
DOI: 10.1002/dvg.20299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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