Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry.

doi:10.3899/jrheum.120989

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Article

Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry.

The Journal of rheumatology - 1 Jun 2013

Ramos Paula S, Oates James C, Kamen Diane L, Williams Adrienne H, Gaffney Patrick M, Kelly Jennifer A, Kaufman Kenneth M, Kimberly Robert P, Niewold Timothy B, Jacob Chaim O, Tsao Betty P, Alarcón Graciela S, Brown Elizabeth E, Edberg Jeffrey C, Petri Michelle A, Ramsey-Goldman Rosalind, Reveille John D, Vilá Luis M, James Judith A, Guthridge Joel M, Merrill Joan T, Boackle Susan A, Freedman Barry I, Scofield R Hal, Stevens Anne M, Vyse Timothy J, Criswell Lindsey A, Moser Kathy L, Alarcón-Riquelme Marta E, Langefeld Carl D, Harley John B, Gilkeson Gary S

Abstract excerpt

OBJECTIVE: Little is known about the genetic etiology of systemic lupus erythematosus (SLE) in individuals of African ancestry, despite its higher prevalence and greater disease severity. Overproduction of nitric oxide (NO) and reactive oxygen species are implicated in the pathogenesis and severi...

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Identifiers

PMID: 23637325
DOI: 10.3899/jrheum.120989
PMCID: PMC3735344

Genes

GSR
NDUFS4
NOS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23637325-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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