Article
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.
PLoS genetics - 1 May 2011
Zhao Jian, Wu Hui, Khosravi Melanie, Cui Huijuan, Qian Xiaoxia, Kelly Jennifer A, Kaufman Kenneth M, Langefeld Carl D, Williams Adrienne H, Comeau Mary E, Ziegler Julie T, Marion Miranda C, Adler Adam, Glenn Stuart B, Alarcón-Riquelme Marta E, Pons-Estel Bernardo A, Harley John B, Bae Sang-Cheol, Bang So-Young, Cho Soo-Kyung, Jacob Chaim O, Vyse Timothy J, Niewold Timothy B, Gaffney Patrick M, Moser Kathy L, Kimberly Robert P, Edberg Jeffrey C, Brown Elizabeth E, Alarcon Graciela S, Petri Michelle A, Ramsey-Goldman Rosalind, Vilá Luis M, Reveille John D, James Judith A, Gilkeson Gary S, Kamen Diane L, Freedman Barry I, Anaya Juan-Manuel, Merrill Joan T, Criswell Lindsey A, Scofield R Hal, Stevens Anne M, Guthridge Joel M, Chang Deh-Ming, Song Yeong Wook, Park Ji Ah, Lee Eun Young, Boackle Susan A, Grossman Jennifer M, Hahn Bevra H, Goodship Timothy H J, Cantor Rita M, Yu Chack-Yung, Shen Nan, Tsao Betty P
Abstract excerpt
Systemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding complement regulator factor H (CFH) and five CFH-related proteins (CFHR1-CFHR5) within the chromosome 1q32 locus linked to SLE, have been associated with multiple human diseases and may contribute to dysregulated complement activation predisposing to SLE. We...
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