Article
Serologic features of cohorts with variable genetic risk for systemic lupus erythematosus.
Molecular medicine (Cambridge, Mass.) - 1 Jun 2018
Bhattacharya Jyotsna, Pappas Karalyn, Toz Bahtiyar, Aranow Cynthia, Mackay Meggan, Gregersen Peter K, Doumbo Ogobara, Traore Abdel Kader, Lesser Martin L, McMahon Maureen, Utset Tammy, Silverman Earl, Levy Deborah, McCune William J, Jolly Meenakshi, Wallace Daniel, Weisman Michael, Romero-Diaz Juanita, Diamond Betty
Abstract excerpt
BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease with genetic, hormonal, and environmental influences. In Western Europe and North America, individuals of West African descent have a 3-4 fold greater incidence of SLE than Caucasians. Paradoxically, West Africans in sub-Saharan Africa appear to have a low incidence of SLE, and some studies suggest a milder disease with less nephritis. In...
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