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Article

Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1.

Nature - 20 Jun 2013

Law Julie A, Du Jiamu, Hale Christopher J, Feng Suhua, Krajewski Krzysztof, Palanca Ana Marie S, Strahl Brian D, Patel Dinshaw J, Jacobsen Steven E

Abstract excerpt

DNA methylation is an epigenetic modification that has critical roles in gene silencing, development and genome integrity. In Arabidopsis, DNA methylation is established by DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) and targeted by 24-nucleotide small interfering RNAs (siRNAs) through a pathway termed RNA-directed DNA methylation (RdDM). This pathway requires two plant-specific RNA polymerases: Pol-IV, which...

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Identifiers

PMID: 23636332
DOI: 10.1038/nature12178
PMCID: PMC4119789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1.PMID 23636332Read ↗

SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV.Semantic proximity Read ↗

SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation.Semantic proximity Read ↗

DTF1 is a core component of RNA-directed DNA methylation and may assist in the recruitment of Pol IV.Semantic proximity Read ↗

Spatial and functional relationships among Pol V-associated loci, Pol IV-dependent siRNAs, and cytosine methylation in the Arabidopsis epigenome.Semantic proximity Read ↗

NRPD4, a protein related to the RPB4 subunit of RNA polymerase II, is a component of RNA polymerases IV and V and is required for RNA-directed DNA methylation.Semantic proximity Read ↗

A conserved transcriptional regulator is required for RNA-directed DNA methylation and plant development.Semantic proximity Read ↗

RNA-directed DNA methylation mediated by DRD1 and Pol IVb: a versatile pathway for transcriptional gene silencing in plants.Semantic proximity Read ↗

DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons.Semantic proximity Read ↗

Maize RNA PolIV affects the expression of genes with nearby TE insertions and has a genome-wide repressive impact on transcription.Semantic proximity Read ↗

A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis.Semantic proximity Read ↗

An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation.Semantic proximity Read ↗

RNA-directed DNA methylation and plant development require an IWR1-type transcription factor.Semantic proximity Read ↗

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