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Helicobacter urease–induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma

27 Jul 2015

Abstract excerpt

Inflammasome activation and caspase-1-dependent (CASP1-dependent) processing and secretion of IL-1β and IL-18 are critical events at the interface of the bacterial pathogen Helicobacter pylori with its host. Whereas IL-1β promotes Th1 and Th17 responses and gastric immunopathology, IL-18 is required for Treg differentiation, H. pylori persistence, and protection against allergic asthma, which is a hallmark of H....

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PMID: 26214524
DOI: 10.1172/jci79337

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