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Article

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2017

Biagioli Michele, Carino Adriana, Cipriani Sabrina, Francisci Daniela, Marchianò Silvia, Scarpelli Paolo, Sorcini Daniele, Zampella Angela, Fiorucci Stefano

Abstract excerpt

GPBAR1 (TGR5 or M-BAR) is a G protein-coupled receptor for secondary bile acids that is highly expressed in monocytes/macrophages. In this study, we aimed to determine the role of GPBAR1 in mediating leukocyte trafficking in chemically induced models of colitis and investigate the therapeutic potential of BAR501, a small molecule agonist for GPBAR1. These studies demonstrated that GPBAR1 gene ablation enhanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28607110
DOI: 10.4049/jimmunol.1700183

Genes

GPBAR1
CCR7
CCL2
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis.PMID 28607110Read ↗

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