Article
Resistance Against Leishmania major Infection Depends on Microbiota-Guided Macrophage Activation.
Frontiers in immunology - 1 Jan 2021
Lopes Mateus Eustáquio, Dos Santos Liliane Martins, Sacks David, Vieira Leda Quercia, Carneiro Matheus B
Abstract excerpt
Innate immune cells present a dual role during leishmaniasis: they constitute the first line of host defense but are also the main host cells for the parasite. Response against the infection that results in the control of parasite growth and lesion healing depends on activation of macrophages into a classical activated phenotype. We report an essential role for the microbiota in driving macrophage and...
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