Article
Recurring mutations found by sequencing an acute myeloid leukemia genome.
The New England journal of medicine - 10 Sept 2009
Mardis Elaine R, Ding Li, Dooling David J, Larson David E, McLellan Michael D, Chen Ken, Koboldt Daniel C, Fulton Robert S, Delehaunty Kim D, McGrath Sean D, Fulton Lucinda A, Locke Devin P, Magrini Vincent J, Abbott Rachel M, Vickery Tammi L, Reed Jerry S, Robinson Jody S, Wylie Todd, Smith Scott M, Carmichael Lynn, Eldred James M, Harris Christopher C, Walker Jason, Peck Joshua B, Du Feiyu, Dukes Adam F, Sanderson Gabriel E, Brummett Anthony M, Clark Eric, McMichael Joshua F, Meyer Rick J, Schindler Jonathan K, Pohl Craig S, Wallis John W, Shi Xiaoqi, Lin Ling, Schmidt Heather, Tang Yuzhu, Haipek Carrie, Wiechert Madeline E, Ivy Jolynda V, Kalicki Joelle, Elliott Glendoria, Ries Rhonda E, Payton Jacqueline E, Westervelt Peter, Tomasson Michael H, Watson Mark A, Baty Jack, Heath Sharon, Shannon William D, Nagarajan Rakesh, Link Daniel C, Walter Matthew J, Graubert Timothy A, DiPersio John F, Wilson Richard K, Ley Timothy J
Abstract excerpt
BACKGROUND: The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not yet known. METHODS: We used massively parallel DNA sequencing to obtain a very high level of coverage (approximately 98%) of a primary, cytogenetically normal, de novo genome for AML with minimal maturation (AML-M1) and a matched normal skin genome. RESULTS: We identified 12 acquired...
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