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Article

Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling.

Proceedings of the National Academy of Sciences of the United States of America - 14 May 2013

Lin Xi, Liu Baohui, Yang Xiangsheng, Yue Xiaojing, Diao Lixia, Wang Jing, Chang Jiang

Abstract excerpt

Rho family guanosine triphosphatase (GTPase) 3 (Rnd3), a member of the small Rho GTPase family, is involved in the regulation of cell actin cytoskeleton dynamics, cell migration, and proliferation through the Rho kinase-dependent signaling pathway. We report a role of Rnd3 in the pathogenesis of hydrocephalus disorder. Mice with Rnd3 genetic deletion developed severe obstructive hydrocephalus with enlargement of...

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Identifiers

PMID: 23630292
DOI: 10.1073/pnas.1219995110
PMCID: PMC3657816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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