Article
Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3.
Brain research. Molecular brain research - 30 Mar 2004
Kuramoto Takashi, Kuwamura Mitsuru, Serikawa Tadao
Abstract excerpt
Rats homozygous for the spontaneous cerebellar vermis defect mutation (cvd) or hobble mutation (hob) exhibit cerebellar and midbrain defects, possibly as a result of abnormal neuronal migration. Both mutant rats demonstrate laminar structure abnormalities in the fused cerebellar hemispheres and ectopic cerebellar tissues in the cerebello-pontine junction. Previous genetic studies showed that cvd and hob were...
Topics
- Animals
- Cell Movement
- Cerebellum
- Codon, Nonsense
- DNA, Complementary
- Frameshift Mutation
- Gene Expression Regulation, Developmental
- Mice
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Nerve Growth Factors
- Nerve Tissue Proteins