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Article

The GTPase-deficient Rnd proteins are stabilized by their effectors.

The Journal of biological chemistry - 7 Sept 2012

Goh Liuh Ling, Manser Ed

Abstract excerpt

Rnd proteins are Rho family GTP-binding proteins with cellular functions that antagonize RhoA signaling. We recently described a new Rnd3 effector Syx, also named PLEKHG5, that interacts with Rnds via a Raf1-like "Ras-binding domain." Syx is a multidomain RhoGEF that participates in early zebrafish development. Here we demonstrated that Rnd1, Rnd2, and Rnd3 stability is acutely dependent on interaction with their...

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Identifiers

PMID: 22807448
DOI: 10.1074/jbc.M111.327056
PMCID: PMC3442376

Genes

PAK1
PLEKHG5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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