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Article

A Rnd3/p190RhoGAP pathway regulates RhoA activity in idiopathic pulmonary fibrosis fibroblasts.

Molecular biology of the cell - 1 Sept 2018

Monaghan-Benson Elizabeth, Wittchen Erika S, Doerschuk Claire M, Burridge Keith

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is an incurable disease of the lung that is characterized by excessive deposition of extracellular matrix (ECM), resulting in disruption of normal lung function. The signals regulating fibrosis include both transforming growth factor beta (TGF-β) and tissue rigidity and a major signaling pathway implicated in fibrosis involves activation of the GTPase RhoA. During studies...

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Identifiers

PMID: 29995590
DOI: 10.1091/mbc.E17-11-0642
PMCID: PMC6249798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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