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Article

Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb.

Genetics - 1 Nov 2014

Neufeld Stanley J, Wang Fan, Cobb John

Abstract excerpt

The growth and development of the vertebrate limb relies on homeobox genes of the Hox and Shox families, with their independent mutation often giving dose-dependent effects. Here we investigate whether Shox2 and Hox genes function together during mouse limb development by modulating their relative dosage and examining the limb for nonadditive effects on growth. Using double mRNA fluorescence in situ hybridization...

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Share to DNA-Binding Proteins
Share to Epistasis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Genes, Homeobox

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Source

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Identifiers

PMID: 25217052
DOI: 10.1534/genetics.114.167460
PMCID: PMC4224156

Genes

SHOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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