Article
Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility.
Nature - 25 Apr 2013
Xu Heping, Li Xuanying, Liu Dan, Li Jianfu, Zhang Xu, Chen Xin, Hou Shiyue, Peng Lixia, Xu Chenguang, Liu Wanli, Zhang Lianfeng, Qi Hai
Abstract excerpt
Germinal centres support antibody affinity maturation and memory formation. Follicular T-helper cells promote proliferation and differentiation of antigen-specific B cells inside the follicle. A genetic deficiency in the inducible co-stimulator (ICOS), a classic CD28 family co-stimulatory molecule highly expressed by follicular T-helper cells, causes profound germinal centre defects, leading to the view that ICOS...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.