Article
Chimera analysis of the Clock mutation in mice shows that complex cellular integration determines circadian behavior.
Cell - 6 Apr 2001
Low-Zeddies S S, Takahashi J S
Abstract excerpt
The Clock mutation lengthens periodicity and reduces amplitude of circadian rhythms in mice. The effects of Clock are cell intrinsic and can be observed at the level of single neurons in the suprachiasmatic nucleus. To address how cells of contrasting genotype functionally interact in vivo to control circadian behavior, we have analyzed a series of Clock mutant mouse aggregation chimeras. Circadian behavior in...
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