Polymorphisms in histone deacetylases improve the predictive value of IL-28B for chronic hepatitis C therapy.

doi:10.1038/gene.2013.24

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Article

Polymorphisms in histone deacetylases improve the predictive value of IL-28B for chronic hepatitis C therapy.

Genes and immunity - 1 Jan 2000

López-Rodríguez R, Hernández-Bartolomé Á, Borque M J, Rodríguez-Muñoz Y, Martín-Vílchez S, Trapero-Marugán M, García-Buey L, Muñoz de Rueda P, Rodrigo L, Vidal-Castiñeira J R, Salmerón J, Moreno-Otero R, Sanz-Cameno P

Abstract excerpt

Histone deacetylases (HDACs) influence many cellular processes, including the modulation of signal transducer and activator of transcription activity (STAT) in response to interferon (IFN). To identify genetic markers that help optimize the IL-28B prediction of chronic hepatitis C (CHC) sustained virological response (SVR), we evaluated 27 single-nucleotide polymorphisms (SNPs) in HDAC1-11. Three SNPs, rs3778216,...

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Identifiers

PMID: 23615070
DOI: 10.1038/gene.2013.24

Genes

HDAC2
HDAC3
HDAC5
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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