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Article

A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection.

Journal of viral hepatitis - 1 Jan 2009

Zhou J, Smith D K, Lu L, Poon V K M, Ng F, Chen D-Q, Huang J-D, Yuen K-Y, Cao K-Y, Zheng B-J

Abstract excerpt

The type I interferon (IFN-alpha/beta) receptor 1 (IFNAR1) mediates the potent antiviral and immuno-regulatory effects of IFN-alpha/beta that are believed to be pivotal to eradicate hepatitis B virus (HBV) infection. IFNAR1 promoter polymorphisms (at -568/-77) have been shown to be associated with susceptibility to chronic HBV infection; however, whether these markers are genetic determinants of HBV infection...

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Topics

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Share to Amino Acid Substitution
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Hepatitis B, Chronic

Share to Mutation, Missense

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Share to Polymorphism, Restriction Fragment Length

Share to Receptor, Interferon alpha-beta

Source

Identifiers

PMID: 18761606
DOI: 10.1111/j.1365-2893.2008.01040.x

Genes

IFNAR1

Provenance

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