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Article

Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2008

Kubota Takuo, Michigami Toshimi, Sakaguchi Naoko, Kokubu Chikara, Suzuki Akira, Namba Noriyuki, Sakai Norio, Nakajima Shigeo, Imai Kenji, Ozono Keiichi

Abstract excerpt

Low-density lipoprotein receptor-related protein 5 (LRP5) regulates bone acquisition by controlling bone formation. Because roles of LRP6, another co-receptor for Wnts, in postnatal bone metabolism have not been fully elucidated, we studied bone phenotype in mice harboring an Lrp6 hypomorphic mutation, ringelschwanz (rs), and characterized the mutant protein. First, we performed pQCT, bone histomorphometry, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18505367
DOI: 10.1359/jbmr.080512

Genes

LRP5
LRP6

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Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd.PMID 18505367Read ↗

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