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Article

A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family.

Aging cell - 1 Aug 2013

Tan Qihua, Soerensen Mette, Kruse Torben A, Christensen Kaare, Christiansen Lene

Abstract excerpt

Genetic interactions or epistasis could make a substantial contribution to variation in human complex traits including longevity. However, detecting epistatic interactions in high dimensional datasets is difficult due to various reasons including multiple testing of correlated tests. We introduce a novel permutation strategy to the case-only analysis of gene-by-gene interaction using multiple SNPs. The method is...

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Identifiers

PMID: 23607278
DOI: 10.1111/acel.12092
PMCID: PMC3714332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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