Article
An "almost exhaustive" search-based sequential permutation method for detecting epistasis in disease association studies.
Genetic epidemiology - 1 Jul 2010
Ma Li, Assimes Themistocles L, Asadi Narges B, Iribarren Carlos, Quertermous Thomas, Wong Wing H
Abstract excerpt
Due to the complex nature of common diseases, their etiology is likely to involve "uncommon but strong" (UBS) interactive effects--i.e. allelic combinations that are each present in only a small fraction of the patients but associated with high disease risk. However, the identification of such ef...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.