Article
An "almost exhaustive" search-based sequential permutation method for detecting epistasis in disease association studies.
Genetic epidemiology - 1 Jul 2010
Ma Li, Assimes Themistocles L, Asadi Narges B, Iribarren Carlos, Quertermous Thomas, Wong Wing H
Abstract excerpt
Due to the complex nature of common diseases, their etiology is likely to involve "uncommon but strong" (UBS) interactive effects--i.e. allelic combinations that are each present in only a small fraction of the patients but associated with high disease risk. However, the identification of such effects using standard methods for testing association can be difficult. In this work, we introduce a method for testing...
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