Article
A polymorphism affecting MYB binding within the promoter of the PDCD4 gene is associated with severe asthma in children.
Human mutation - 1 Aug 2013
Binia Aristea, Van Stiphout Nicole, Liang Liming, Michel Sven, Bhavsar Pankaj K, Fan Chung K, Brightling Chris E, Barnes Peter J, Kabesch Michael, Bush Andrew, Cookson William O C, Moffatt Miriam F
Abstract excerpt
A previous genome-wide association study in asthma revealed putative associations that merit further investigation. In this study, the genome-wide significant associations of SNPs at the 5% false discovery rate were examined in independent groups of severe asthmatics. The panel consisted of 397 severe asthmatic adults, 116 severe asthmatic children, and a collection of 207 family-trios with an asthmatic proband....
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