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Article

p21 induces a senescence program and skeletal muscle dysfunction

9 Dec 2022

Abstract excerpt

Recent work has established associations between elevated p21, the accumulation of senescent cells, and skeletal muscle dysfunction in mice and humans. Using a mouse model of p21 overexpression (p21OE), we examined if p21 mechanistically contributes to cellular senescence and pathological features in skeletal muscle. We show that p21 induces several core properties of cellular senescence in skeletal muscle,...

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PMID: 36509362
DOI: 10.1016/j.molmet.2022.101652

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