Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

iPSC-Derived Neural Stem Cells Act via Kinase Inhibition to Exert Neuroprotective Effects in Spinal Muscular Atrophy with Respiratory Distress Type 1

4 Jul 2014

Abstract excerpt

Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a motor neuron disease caused by mutations in the IGHMBP2 gene, without a cure. Here, we demonstrate that neural stem cells (NSCs) from human-induced pluripotent stem cells (iPSCs) have therapeutic potential in the context of SMARD1. We show that upon transplantation NSCs can appropriately engraft and differentiate in the spinal cord of SMARD1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Neurogenetic and Muscular Disorders Research
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25254343
DOI: 10.1016/j.stemcr.2014.06.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

iPSC-Derived Neural Stem Cells Act via Kinase Inhibition to Exert Neuroprotective Effects in Spinal Muscular Atrophy with Respiratory Distress Type 1PMID 25254343Read ↗

Clinical and molecular features and therapeutic perspectives of spinal muscular atrophy with respiratory distress type 1Semantic proximity Read ↗

Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1).Semantic proximity Read ↗

Gene therapy rescues disease phenotype in a spinal muscular atrophy with respiratory distress type 1 (SMARD1) mouse modelSemantic proximity Read ↗

Hypoimmunogenic human motor neurons induced from iPSCs in vivo substantially ameliorate ALS disease in large animal modelsSemantic proximity Read ↗

Genetic Correction of Human Induced Pluripotent Stem Cells from Patients with Spinal Muscular AtrophySemantic proximity Read ↗

Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice.Semantic proximity Read ↗

Spinal muscular atrophy with respiratory distress type 1: Clinical phenotypes, molecular pathogenesis and therapeutic insights.Semantic proximity Read ↗

Characterization of human-iPSCs derived spinal motor neurons by single-cell RNA sequencingSemantic proximity Read ↗

Transplanted ALDHhiSSClo neural stem cells generate motor neurons and delay disease progression of nmd mice, an animal model of SMARD1Semantic proximity Read ↗

Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factorsSemantic proximity Read ↗

Patient-Specific Cells for Modeling and Decoding Amyotrophic Lateral Sclerosis: Advances and Challenges.Semantic proximity Read ↗

Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.