Article
Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations.
International journal of molecular sciences - 21 Oct 2022
Maestro Ines, de la Ballina Laura R, Porras Gracia, Corrochano Silvia, De Lago Eva, Simonsen Anne, Boya Patricia, Martinez Ana
Abstract excerpt
Mitophagy is the selective degradation of mitochondria by autophagy. It promotes the turnover of mitochondria and prevents the accumulation of dysfunctional mitochondria, which can lead to cellular degeneration. Mitophagy is known to be altered in several pathological conditions, especially in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). We recently demonstrated an increase in autophagy...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.