Article
A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells.
PloS one - 1 Jan 2015
Li Ying, Balasubramanian Umamahesw, Cohen Devon, Zhang Ping-Wu, Mosmiller Elizabeth, Sattler Rita, Maragakis Nicholas J, Rothstein Jeffrey D
Abstract excerpt
Amyotrophic lateral sclerosis is a progressive disease characterized by the loss of upper and lower motor neurons, leading to paralysis of voluntary muscles. About 10% of all ALS cases are familial (fALS), among which 15-20% are linked to Cu/Zn superoxide dismutase (SOD1) mutations, usually inherited in an autosomal dominant manner. To date only one FDA approved drug is available which increases survival...
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