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Article

A screen for regulators of survival of motor neuron protein levels.

Nature chemical biology - 19 Jun 2011

Makhortova Nina R, Hayhurst Monica, Cerqueira Antonio, Sinor-Anderson Amy D, Zhao Wen-Ning, Heiser Patrick W, Arvanites Anthony C, Davidow Lance S, Waldon Zachary O, Steen Judith A, Lam Kelvin, Ngo Hien D, Rubin Lee L

Abstract excerpt

The motor neuron disease spinal muscular atrophy (SMA) results from mutations that lead to low levels of the ubiquitously expressed protein survival of motor neuron (SMN). An ever-increasing collection of data suggests that therapeutics that elevate SMN may be effective in treating SMA. We execut...

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Identifiers

PMID: 21685895
DOI: 10.1038/nchembio.595
PMCID: PMC3236614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21685895-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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A screen for regulators of survival of motor neuron protein levels.PMID 21685895Read ↗

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Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes.Semantic proximity Read ↗

Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathwaySemantic proximity Read ↗

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