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Article

Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer's Disease Pathology.

Journal of Alzheimer's disease : JAD - 6 Jul 2016

Bangen Katherine J, Himali Jayandra J, Beiser Alexa S, Nation Daniel A, Libon David J, Fox Caroline S, Seshadri Sudha, Wolf Philip A, McKee Ann C, Au Rhoda, Delano-Wood Lisa

Abstract excerpt

Elevated blood glucose and the apolipoprotein (APOE) ɛ4 allele have both been associated with increased dementia risk; however, the neuropathological mechanisms underlying these associations remain unclear. We examined the impact of APOE genotype and midlife blood glucose on post-mortem vascular and Alzheimer's disease (AD) neuropathology. Ninety-four participants from the Framingham Heart Study without diagnosed...

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Source

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Identifiers

PMID: 27392855
DOI: 10.3233/JAD-160163
PMCID: PMC5494258

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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