Update on pathogenesis of cystic fibrosis lung disease

Abstract excerpt

PURPOSE OF REVIEW: It has been an ongoing challenge to translate knowledge pertaining to the molecular basis of cystic fibrosis (CF) into a clear understanding of the development of CF lung disease. Various hypotheses have attempted to explain the apparent breach of innate defenses in CF, although a definitive explanation has been elusive. RECENT FINDINGS: Recent data suggest that altered ion transport...

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