Article

Lack of <i>Kcnn4</i> improves mucociliary clearance in muco-obstructive lung disease

2020-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Airway mucociliary clearance (MCC) is the main mechanism of lung defense keeping the airways free of infection and mucus obstruction. Airways surface liquid (ASL) volume, ciliary beating and mucus are central for proper MCC, and are critically regulated by sodium (Na + ) absorption and anion secretion. Impaired MCC is a key feature of muco-obstructive disease. The calcium-activated potassium (K...

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Literature Corpus work: 3e945ef9-da90-5d37-8154-38e5b0db9df4
DOI: 10.1101/2020.05.06.079707

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