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Article

Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis.

Genes - 29 May 2020

Liu Zhongyu, Anderson Justin D, Deng Lily, Mackay Stephen, Bailey Johnathan, Kersh Latona, Rowe Steven M, Guimbellot Jennifer S

Abstract excerpt

We describe a human nasal epithelial (HNE) organoid model derived directly from patient samples that is well-differentiated and recapitulates the airway epithelium, including the expression of cilia, mucins, tight junctions, the cystic fibrosis transmembrane conductance regulator (CFTR), and ionocytes. This model requires few cells compared to airway epithelial monolayer cultures, with multiple outcome...

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Share to Cells, Cultured
Share to Cystic Fibrosis
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epithelial Cells

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Share to Nasal Mucosa

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Source

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Identifiers

PMID: 32485957
DOI: 10.3390/genes11060603
PMCID: PMC7349680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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