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Article

Modulation by dietary fat and carbohydrate of IRS1 association with type 2 diabetes traits in two populations of different ancestries.

Diabetes care - 1 Sept 2013

Zheng Ju-Sheng, Arnett Donna K, Parnell Laurence D, Smith Caren E, Li Duo, Borecki Ingrid B, Tucker Katherine L, Ordovás José M, Lai Chao-Qiang

Abstract excerpt

OBJECTIVE: Insulin receptor substrate 1 (IRS1) is central to insulin signaling pathways. This study aimed to examine the association of IRS1 variants with insulin resistance (IR) and related phenotypes, as well as potential modification by diet. RESEARCH DESIGN AND METHODS: Two IRS1 variants (rs7578326 and rs2943641) identified by genome-wide association studies as related to type 2 diabetes were tested for their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23596181
DOI: 10.2337/dc12-2607
PMCID: PMC3747864

Genes

IRS1

Provenance

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