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Article

Circulating 25-hydroxyvitamin D, IRS1 variant rs2943641, and insulin resistance: replication of a gene-nutrient interaction in 4 populations of different ancestries.

Clinical chemistry - 1 Jan 2014

Zheng Ju-Sheng, Parnell Laurence D, Smith Caren E, Lee Yu-Chi, Jamal-Allial Aziza, Ma Yiyi, Li Duo, Tucker Katherine L, Ordovás José M, Lai Chao-Qiang

Abstract excerpt

BACKGROUND: Associations of either insulin receptor substrate 1 (IRS1) variants or circulating 25-hydroxyvitamin D [25(OH)D] with type 2 diabetes (T2D) and insulin resistance (IR) are inconsistent. This study sought to determine whether circulating 25(OH)D modulates the association of a potentially functional variant at IRS1 (rs2943641) with insulin resistance. METHOD: Interaction between IRS1 rs2943641 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24255076
DOI: 10.1373/clinchem.2013.215251
PMCID: PMC4026060

Genes

IRS1

Variants

Provenance

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