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Article

Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos.

Obesity (Silver Spring, Md.) - 1 Nov 2016

Qi Qibin, Gogarten Stephanie M, Emery Leslie S, Louie Tin, Stilp Adrienne, Cai Jianwen, Schneiderman Neil, Avilés-Santa M Larissa, Kaplan Robert C, North Kari E, Laurie Cathy C, Loos Ruth J F, Isasi Carmen R

Abstract excerpt

OBJECTIVE: Associations of IRS1 genetic variation with adiposity and metabolic profile in U.S. Hispanic/Latino individuals of diverse backgrounds were examined. METHODS: Previously genome-wide association study-identified IRS1 variants (rs2943650, rs2972146, rs2943641, and rs2943634) as related to body fat percentage (BF%) and multiple metabolic traits were tested among up to 12,730 adults (5,232 men; 7,515...

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Share to Adiposity
Share to Cholesterol, HDL
Share to Fasting
Share to Glycated Hemoglobin
Share to Hispanic or Latino
Share to Insulin Receptor Substrate Proteins
Share to Metabolome
Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 27663718
DOI: 10.1002/oby.21624
PMCID: PMC5093062

Genes

IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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