Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes.

doi:10.3945/ajcn.112.046474

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Article

Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes.

The American journal of clinical nutrition - 1 Jan 2013

Ericson Ulrika, Rukh Gull, Stojkovic Ivana, Sonestedt Emily, Gullberg Bo, Wirfält Elisabet, Wallström Peter, Orho-Melander Marju

Abstract excerpt

BACKGROUND: The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity. OBJECTIVE: The objective was to examine the interaction...

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Identifiers

PMID: 23221578
DOI: 10.3945/ajcn.112.046474

Genes

IRS1

Variants

rs2943641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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