Article
Low-density lipoprotein receptor-related protein 1 variant interacts with saturated fatty acids in Puerto Ricans.
Obesity (Silver Spring, Md.) - 1 Mar 2013
Smith Caren E, Tucker Katherine L, Lee Yu-Chi, Lai Chao-Qiang, Parnell Laurence D, Ordovás José M
Abstract excerpt
OBJECTIVE: Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor that is highly expressed in adipocytes and the hypothalamus. Animal models and in vitro studies support a role for LRP1 in adipocyte metabolism and leptin signaling, but genetic polymorphisms have not been evaluated for obesity in people. DESIGN AND METHODS: We examined whether dietary fats (eg.,...
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