Article

<i>Dpp6</i> Knockout Mice Exhibit Increased Ethanol Conditioned Place Preference and Acute Ethanol-Induced Anxiolytic Behavior

2025-08-18

Abstract excerpt

The gene DPP6 has been associated with behavioral phenotypes of alcohol use disorder (AUD) in recent human genome wide association studies. DPP6 encodes an auxiliary subunit that modulates A-type voltage-gated potassium channels, particularly Kv4.2. To further assess the role of this gene in ethanol-related traits, we tested Dpp6 knockout (KO) mice for ethanol conditioned place preference (CPP), locomotor activ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7cc01bd9-4461-5be1-aa5b-d5910a4c9596
DOI: 10.1101/2025.08.15.670589

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Dpp6</i> Knockout Mice Exhibit Increased Ethanol Conditioned Place Preference and Acute Ethanol-Induced Anxiolytic BehaviorDOI 10.1101/2025.08.15.670589Read

Nicotinic acetylcholine receptors containing α6 subunits contribute to alcohol reward-related behaviours.Semantic proximity Read

Acute behavioral effects of nicotine in male and female HINT1 knockout mice.Semantic proximity Read

Atp1a2 and Kcnj9 are candidate genes underlying sensitivity to oxycodone-induced locomotor activation and withdrawal-induced anxiety-like behaviors in C57BL/6 substrainsSemantic proximity Read

Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice.Semantic proximity Read

Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination.Semantic proximity Read

Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis.Semantic proximity Read

Genetic relationship between ethanol-induced conditioned place preference and other ethanol phenotypes in 15 inbred mouse strains.Semantic proximity Read

Increased ethanol drinking in "humanized" mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms.Semantic proximity Read

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.Semantic proximity Read

Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons.Semantic proximity Read

Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant mice.Semantic proximity Read

Screening for ENU-induced mutations in mice that result in aberrant ethanol-related phenotypes.Semantic proximity Read