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Article

Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Jul 2010

Hendrickson Linzy M, Zhao-Shea Rubing, Pang Xueyan, Gardner Paul D, Tapper Andrew R

Abstract excerpt

Recently, the smoking cessation therapeutic varenicline, a nicotinic acetylcholine receptor (nAChR) partial agonist, has been shown to reduce alcohol consumption. However, the mechanism and nAChR subtype(s) involved are unknown. Here we demonstrate that varenicline and alcohol exposure, either alone or in combination, selectively activates dopaminergic (DAergic) neurons within the posterior, but not the anterior,...

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Identifiers

PMID: 20668200
DOI: 10.1523/JNEUROSCI.2601-10.2010
PMCID: PMC2941435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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