Article
Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Jul 2010
Drenan Ryan M, Grady Sharon R, Steele Andrew D, McKinney Sheri, Patzlaff Natalie E, McIntosh J Michael, Marks Michael J, Miwa Julie M, Lester Henry A
Abstract excerpt
Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh receptors (nAChRs) on DA presynaptic terminals. DA neurons selectively express alpha6* nAChRs, which show high ACh and nicotine sensitivity. To help identify nAChR subtypes that control DA transmission, we studied transgenic mice expressing hypersensitive alpha6(L9'S)* receptors....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.