Article
Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus.
PloS one - 1 Jan 2013
Venit Tomáš, Dzijak Rastislav, Kalendová Alžběta, Kahle Michal, Rohožková Jana, Schmidt Volker, Rülicke Thomas, Rathkolb Birgit, Hans Wolfgang, Bohla Alexander, Eickelberg Oliver, Stoeger Tobias, Wolf Eckhard, Yildirim Ali Önder, Gailus-Durner Valérie, Fuchs Helmut, de Angelis Martin Hrabě, Hozák Pavel
Abstract excerpt
BACKGROUND: Nuclear myosin I (NM1) is a nuclear isoform of the well-known "cytoplasmic" Myosin 1c protein (Myo1c). Located on the 11(th) chromosome in mice, NM1 results from an alternative start of transcription of the Myo1c gene adding an extra 16 amino acids at the N-terminus. Previous studies revealed its roles in RNA Polymerase I and RNA Polymerase II transcription, chromatin remodeling, and chromosomal...
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