Article
Myo1c is an unconventional myosin required for zebrafish glomerular development.
Kidney international - 1 Dec 2013
Arif Ehtesham, Kumari Babita, Wagner Mark C, Zhou Weibin, Holzman Lawrence B, Nihalani Deepak
Abstract excerpt
The targeting and organization of podocyte slit diaphragm proteins nephrin and neph1 is critical for development and maintenance of a functional glomerular filtration barrier. Myo1c is a non-muscle myosin motor protein that interacts directly with nephrin and neph1, and mediates their intracellular transport to the podocyte intercellular junction. Here we investigated the necessity of Myo1c in podocyte...
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