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Article

Cytoplasmic and nuclear retained DMPK mRNAs are targets for RNA interference in myotonic dystrophy cells.

The Journal of biological chemistry - 29 Apr 2005

Langlois Marc-André, Boniface Christelle, Wang Gang, Alluin Jessica, Salvaterra Paul M, Puymirat Jack, Rossi John J, Lee Nan Sook

Abstract excerpt

Small interfering RNA (siRNA) duplexes induce the specific cleavage of target RNAs in mammalian cells. Their involvement in down-regulation of gene expression is termed RNA interference (RNAi). It is widely believed that RNAi predominates in the cytoplasm. We report here the co-existence of cytoplasmic and nuclear RNAi phenomena in primary human myotonic dystrophy type 1 (DM1) cells by targeting myotonic...

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Source

Identifiers

PMID: 15722335
DOI: 10.1074/jbc.M501591200

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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